A clinical prediction rule for pulmonary tuberculosis in emergency departments

作者：Solari L; Acuna Villaorduna C^*; Soto A; Agapito J; Perez F; Samalvides F; Zegarra J; Diaz J; Gotuzzo E; Van der Stuyft P

来源：International Journal of Tuberculosis and Lung Disease, 2008, 12(6): 619-624.

• pulmonary tuberculosis
• clinical prediction rule
• isolation
• score
• emergency department

SETTING: University-affiliated hospital located in an area with a high incidence of pulmonary tuberculosis (PTB). OBJECTIVE: To develop a clinical prediction rule (CPR) based on information obtainable on admission, to permit rapid identification of patients with PTB.
DESIGN: Information from patients with respiratory symptoms who attended the emergency department.of Cayetano Heredia Hospital, Lima, Peru, was collected prospectively. Clinical symptoms, past medical history, demographic data and results of chest X-rays (CXRs), sputum smear and culture in Lowenstein-jensen media were obtained. Based on logistic regression, we constructed a scoring system to predict PTB.
RESULTS: A total of 345 patients were enrolled in the study, including 109 (31 %)culture-proven PTB cases. In logistic regression analysis, we found age, previous history of PTB, weight loss, presence of cavities, upper lobe infiltrate and miliary pattern on CXR as independent predictors of PTB. We designed a scoring system with these variables, taking into account their statistical weight. The score attained 93% sensitivity and 42% specificity.
CONCLUSION: The CPR that was developed performed well in our population. It merits further validation in other settings. It should not, however, replace, but should complement sputum microscopy when deciding on isolation, and it does not preclude microbiology in making a definitive diagnosis.

• 出版日期2008-6
• 单位河北医科大学