Differential effects on p53-mediated cell cycle arrest vs. apoptosis by p90

作者：Dai Chao; Tang Yi; Jung Sung Yun; Qin Jun; Aaronson Stuart A; Gu Wei^*

来源：Proceedings of the National Academy of Sciences, 2011, 108(47): 18937-18942.

DOI：10.1073/pnas.1110988108

p53 functions as a central node for organizing whether the cell responds to stress with apoptosis or cell cycle arrest; however, the molecular events that lead to apoptotic responses are not completely understood. Here, we identified p90 (also called Coiled-Coil Domain Containing 8) as a unique regulator for p53. p90 has no obvious effects on either the levels of p53 or p53-mediated cell cycle arrest but is specifically required for p53-mediated apoptosis upon DNA damage. Notably, p90 is crucial for Tip60-dependent p53 acetylation at Lys120, therefore facilitating activation of the proapoptotic targets. These studies indicate that p90 is a critical cofactor for p53-mediated apoptosis through promoting Tip60-mediated p53 acetylation.

• 出版日期2011-11-22