Macleayine, a new alkaloid from Macleaya cordata

作者：Sai, Chun-Mei; Qin, Ning-Bo; Jia, Cui-Cui; Li, Da-Hong; Wang, Kai-Bo; Pei, Yue-Hu; Bai, Jiao; Li, Zhan-Lin^*; Hua, Hui-Ming^*

来源：Chinese Chemical Letters, 2016, 27(11): 1717-1720.

DOI：10.1016/j.cclet.2016.06.017

• Macleayine
• A natural occurring alkaloid
• Quantum chemistry calculations
• ECD calculation
• Plausible biogenetic pathway
• Macleaya cordata

Macleayine (1), a new natural occurring alkaloid with a unique Spiro [furanone-piperidinedione] framework, was isolated from the aerial parts of Macleaya cordata. Its unusual structure was established by extensive spectroscopic analyses, computer-assisted structure elucidation software (ACD/Structure Elucidator), quantum chemistry calculations and ECD calculation. The result of virtual molecular docking predicted the compound can enhance the effects of insulin, and may be used to treat type II diabetes.

• 出版日期2016-11
• 单位沈阳药科大学