Delayed auditory feedback simulates features of nonfluent primary progressive aphasia

作者：Maruta Carolina; Makhmood Sonya; Downey Laura E; Golden Hannah L; Fletcher Phillip D; Witoonpanich Pirada; Rohrer Jonathan D; Warren Jason D^*

来源：Journal of the Neurological Sciences, 2014, 347(1-2): 345-348.

DOI：10.1016/j.jns.2014.09.039

• Delayed auditory feedback
• Altered auditory feedback
• Dementia
• Progressive aphasia
• Language
• Dorsal pathway

The pathophysiology of nonfluent primary progressive aphasia (nfvPPA) remains poorly understood. Here, we compared quantitatively speech parameters in patients with nfvPPA versus healthy older individuals under altered auditory feedback, which has been shown to modulate normal speech output. Patients (n = 15) and healthy volunteers (n = 17) were recorded while reading aloud under delayed auditory feedback [DAF] with latency 0,50 or 200 ms and under DAF at 200 ms plus 0.5 octave upward pitch shift. DAF in healthy older individuals was associated with reduced speech rate and emergence of speech sound errors, particularly at latency 200 ms. Up to a third of the healthy older group under DAF showed speech slowing and frequency of speech sound errors within the range of the nfvPPA cohort Our findings suggest that (in addition to any anterior, primary language output disorder) these key features of nfvPPA may reflect distorted speech input signal processing, as simulated by DAF. DAF may constitute a novel candidate pathophysiological model of posterior dorsal cortical language pathway dysfunction in nfvPPA.

• 出版日期2014-12-15