Alteration of inhibitory and activating NK cell receptor expression on NK cells in HIV-infected Chinese

作者：Jiang, Yongjun; He, Lei; Chen, Huan; Bice, Tristan; Zhang, Zining; Liu, Ling; Ding, Haibo; Han, Xiaoxu; Shang, Hong^*

来源：Cellular Immunology, 2011, 271(2): 219-226.

DOI：10.1016/j.cellimm.2011.06.026

• NK cells
• NK receptors
• NK subsets
• HIV

Natural killer (NM) cell function, based on the expression of activating and inhibitory natural killer receptors (NKRs), may become abnormal during human immunodeficiency virus (HIV) infection. In this study, we investigated changes in receptor expression with individual and combinational analysis on NM cell subsets in HIV-infected Chinese. The results showed that natural killer group 2 member D (NKG2D) expression on total NM cells decreased significantly in HIV infection, while the expressions of natural killer group 2 member A (NKG2A) and killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail 1 (KIR3DL1) on total NM cells were not significantly different between any of the groups including HIV-positive treatment-naive group, AIDS treatment-naive group, HAART-treatment AIDS group and HIV-negative control group. Individual analysis of NKG2A(+) and KIR3DL1 cells revealed no significant differences in expression in any NK cell subsets between any of the groups, but the combinational analysis of NKG2D(-)NKG2A(+), and NKG2D(-)KIR3DL1(+) on the NM CD56(dim) cell subset in the AIDS group were increased compared to the HIV-negative control group. On the contrary, NKG2D(-)NKG2A(+). expression on the CD56(bright) subset decreased in the AIDS group compared to the control group. Highly active antiretroviral therapy (HAART) treatment almost completely restored the levels of these receptor expressions. The results indicate that the distinct alteration of activating and inhibitory NKR expression on NM cells and its subsets occurred during HIV progression. Moreover, the imbalanced change of activating and inhibitory NKRs on NM cells and its subsets may explain the impaired NM cell immunity in HIV infected individuals.

• 出版日期2011
• 单位中国医科大学