BSA Protein-Mediated Synthesis of Hollow Mesoporous Silica Nanotubes, and Their Carbohydrate Conjugates for Targeting Cancer Cells and Detecting Mycobacteria

作者：Hao Nanjing^*; Li Laifeng; Tang Fangqiong^*

来源：ACS Applied Materials & Interfaces, 2016, 8(43): 29208-29212.

DOI：10.1021/acsami.6b10051

• carbohydrate
• hollow mesoporous silica
• targeting detection
• mycobacteria

A straightforward method was developed to synthesize hollow mesoporous silica nanotubes (HMSNTs) using bovine serum protein (BSA) as the protective coating and phosphate buffered saline (PBS) as the etching agent at room temperature. Galactose-grafted HMSNTs significantly reduced phagocytosis by macrophages, and enhanced cellular uptake by A549 cells via caveolae-mediated uptake pathway. Trehalose-conjugated HMSNTs interacted strongly with mycobacteria, showing the linear detection range from 1 x 10(4) to 1 x 10(8) bacteria/mL and the detection limit of 1 x 10(3) bacteria/mL. In all cases, the hollow nanotube structure showed higher cellular uptake, bacterial binding, and detection efficiency than their spherical counterpart.

• 出版日期2016-11-2
• 单位中国科学院理化技术研究所