Aberrant activation of ROS1 represents a new molecular defect in chronic myelomonocytic leukemia

作者：Cilloni Daniela^*; Carturan Sonia; Bracco Enrico; Campia Valentina; Rosso Valentina; Torti Davide; Calabrese Chiara; Gaidano Valentina; Niparuck Pimjai; Favole Alessandra; Signorino Elisabetta; Iacobucci Ilaria; Morano Annalisa; De Luca Luciana; Musto Pellegrino; Frassoni Francesco; Saglio Giuseppe

来源：Leukemia Research, 2013, 37(5): 520-530.

DOI：10.1016/j.leukres.2013.01.014

• ROS1
• CMML
• Chronic myeloproliferative neoplasms
• Proliferation
• Tyrosine kinase
• Molecular target

Chronic myelomonocytic leukemia (CMML) is a clonal disorder sharing features of myelodysplastic syndromes and chronic myeloproliferative neoplasms. Although rare chromosomal aberrations and point mutations are reported in CMML, the molecular defects underlying CMML are largely unknown. ROS1 encodes a tyrosine kinase that is abnormally expressed and translocated in brain and lung cancers. In this study we show that ROS1 is abnormally activated in the CD34+ compartment of approximately 70% of CMML patients resulting in the activation of the Erk/Akt pathways through the Grb2/SOS complex thus revealing a central oncogenic role for ROS1 in CMML which might represent a molecular target.

• 出版日期2013-5