Association of rs7903146 and rs7085532 polymorphisms in TCF7L2 gene with type 2 diabetes mellitus in a Chinese Uygur population

作者：Wang, Zhiqiang; Li, Yukai; Su, Yinxia; Ma, Qi; Wang, Li; Ding, Lili; Liu, Lina; Zhu, Jun^*; Yao, Hua^*

来源：International Journal of Clinical and Experimental Pathology, 2017, 10(5): 5939-5947.

• TCF7L2
• Chinese Uygur population
• single nucleotide polymorphism
• type 2 diabetes mellitus
• haplo-type

The transcription factor 7-like 2 gene (TCF7L2) has been reported to be strongly associated with an increased risk of type 2 diabetes mellitus (T2DM) in different ethnic populations. The aim of the present study was to investigate whether rs7903146 and rs7085532 polymorphisms in TCF7L2 are associated with susceptibility to T2DM in Chinese Uygur population. We analyzed two single-nucleotide polymorphisms (SNPs) (rs793146, and rs7085532) in 927 Uygur subjects with T2DM and 955 control subjects. Genotyping was performed by Sequenom Massarray platform. The distribution of rs7903146 genotypes showed a significant difference between patients with T2DM and control participants (P = 0.008). In logistic regression analysis, the rs7903146 polymorphism was associated with the risk of developing T2DM in the dominant model after adjustment for potential confounders. General linear model analysis showed rs7903146 was independently associated with increased glucose levels by analyses of the dominant model and additive model after adjustment for covariates (P = 0.005 and P = 0.018, respectively). Our study indicates that rs7903146 polymorphism may play a role in T2DM susceptibility in Chinese Uygur population and is functionally associated with glucose levels, suggesting a mechanistic link between rs7903146 polymorphism and T2DM susceptibility.

• 出版日期2017
• 单位新疆医科大学