A prospective study on the impact of heart rate control achieved with metoprolol on cardiac performance, motor function and quality of life in Chinese chronic heart failure patients

作者：Meng, Yong^*; Liu, Xuelu; Liu, Juan; Cheng, Xianliang

来源：International Journal of Cardiology, 2017, 227: 267-271.

DOI：10.1016/j.ijcard.2016.11.115

• Metoprolol
• Heart rate
• Quality of life
• Motor function
• Cardiac performance
• Heart failure

Background: To prospectively evaluate the impact of metoprolol achieved heart rate (HR) on cardiac-motor function and quality of life (QoL) in chronic heart failure (CHF) patients.
Methods and results: Between February 2013 to April 2016, association of HR reduction with haemodynamic indices, motor function and QoL in CHF patients with HR > 80 bpm receiving metoprolol 23.75 mg or 47.5 mg q. d was studied. Overall, 154 patients (median age, 66.39 years; males, n = 101; females, n = 53) were enrolled, whose average resting HR decreased significantly from baseline value of 82.72 +/- 6.73 to 69.38 +/- 3.57, 67.72 +/- 2.61, 66.50 +/- 3.14 and 64.86 +/- 3.21 bpm in the 1st, 3rd, 6th and 12th months post metoprolol intervention, respectively (P < 0.0001). Similarly, the ejection fraction (r =-0.6461, P < 0.0001), cardiac output (r=-0.5238, P < 0.0001), cardiac index (r=-0.5378, P < 0.0001) and veterans specific activity questionnaire scores (r=-0.4088, P < 0.0001) were significantly associatedwith the reduction in HR after 12months. The improvement in 6-min walk test was independent of HR reduction (P= 0.005). Similarly, QoL asmeasured by short form-8 questionnaire (SF-8) but notMinnesota Livingwith Heart Failurewas significantly improved at the 12thmonth. However, this was not associated with the reductions in HR.
Conclusion: Metoprolol achieved HRcontrolwas associated with improvement in cardiac performance andmotor function but not QoL in patients with CHF.

• 出版日期2017-1-15
• 单位昆明医科大学