Toll-like Receptor Polymorphism Associations With HIV-1 Outcomes Among Sub-Saharan Africans

作者：Mackelprang Romel D; Bigham Abigail W; Celum Connie; de Bruyn Guy; Beima Sofie Kristin; John Stewart Grace; Ronald Allan; Mugo Nelly R; Buckingham Kati J; Bamshad Michael J; Mullins James I; McElrath M Juliana; Lingappa Jairam R^*

来源：Journal of Infectious Diseases, 2014, 209(10): 1623-1627.

DOI：10.1093/infdis/jit807

• Acute Infection
• Genetics
• Heterosexual HIV-1 transmission
• Progression
• Risk Factors
• Viral load
• Toll-like Receptors
• HIV-1 set-point
• HIV-1 acquisition

Objective. We evaluated Toll-like receptors (TLRs) single nucleotide polymorphisms (SNPs) for associations with HIV-1 acquisition, set-point and disease progression in African couples. %26lt;br%26gt;Methods. Seven candidate and 116 haplotype-tagging SNPs (tagSNPs) were genotyped in 504 HIV-1 infected cases, and 343 seronegative controls. %26lt;br%26gt;Results. TLR9 1635A/G was associated with reduced HIV-1 acquisition among HIV-seronegative controls with high but not low HIV-1 exposure (odds ratio [OR] = 0.7; P = .03 and OR = 0.9, P = .5, respectively). TLR7 rs179012 and TLR2 597C/T reduced set-point; the latter modified by time since HIV-1 acquisition. TLR8 1A/G reduced disease progression. %26lt;br%26gt;Conclusions. TLR SNPs impact HIV-1 outcomes with epidemiologic factors modifying these relationships.

• 出版日期2014-5-15