A Genome-Wide Association Scan of RR and QT Interval Duration in 3 European Genetically Isolated Populations The EUROSPAN Project

作者：Marroni Fabio; Pfeufer Arne; Aulchenko Yurii S; Franklin Christopher S; Isaacs Aaron; Pichler Irene; Wild Sarah H; Oostra Ben A; Wright Alan F; Campbell Harry; Witteman Jacqueline C; Kaeaeb Stefan; Hicks Andrew A; Gyllensten Ulf; Rudan Igor; Meitinger Thomas; Pattaro Cristian; van Duijn Cornelia M; Wilson James F; Pramstaller Peter P^*

来源：Circulation-Cardiovascular Genetics, 2009, 2(4): 322-U48.

DOI：10.1161/CIRCGENETICS.108.833806

• genetics
• heart rate
• population

Background-We set out to identify common genetic determinants of the length of the RR and QT intervals in 2325 individuals from isolated European populations.
Methods and Results-We analyzed the heart rate at rest, measured as the RR interval, and the length of the corrected QT interval for association with 318 237 single-nucleotide polymorphisms. The RR interval was associated with common variants within GPR133, a G-protein-coupled receptor (rs885389, P = 3.9 x 10(-8)). The QT interval was associated with the earlier reported NOS1AP gene (rs2880058, P = 2.00 x 10(-10)) and with a region on chromosome 13 (rs2478333, P = 4.34 x 10(-8)), which is 100 kb from the closest known transcript LOC730174 and has previously not been associated with the length of the QT interval.
Conclusion-Our results suggested an association between the RR interval and GPR133 and confirmed an association between the QT interval and NOS1AP. (Circ Cardiovasc Genet. 2009; 2: 322-328.)

• 出版日期2009-8
• 单位河北医科大学