Antioxidant and cytotoxic activities and phytochemical screening of four Philippine medicinal plants

作者：Peteros Nonita P^*; Uy Mylene M

来源：Journal of Medicinal Plants Research, 2010, 4(5): 407-414.

• Philippine medicinal plants
• DPPH radical scavenging activity
• brine shrimp lethality assay
• phytochemical screening

The crude methanol extracts of four Philippine medicinal plants namely Brucea amarissima (Lour.) Merr. Bark, Intsia bijuga (Coebr.) O. Kuntze, Laportea meyeniana Warb, and Pipturus arborescens (Link) C. B. Rob leaves were examined for their antioxidant (radical scavenging) activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical, and cytotoxicity using brine shrimp lethality assay (BSLA). LC(50) values for BSLA ranged from 37.7 to 89.5 mu g/ml, with B. amarissima having the lowest value and therefore the most potent, and L. meyeniana having the highest value. EC(50) values for DPPH radical scavenging activity ranged from 343 to 1846 mu g/ml, with B. amarissima and I. bijuga having the lowest and highest values, respectively. Phytochemical screening revealed the presence of flavonoids, tannins, triterpenes, steroids, anthraquinones, anthrones, flavonoid glycosides, and coumarins, which could be responsible for the bioactivities shown by these plants.

• 出版日期2010-3-4