Anti-inflammatory activity of sulfate-containing phenolic compounds isolated from the leaves of Myrica rubra

作者：Kim Han Hyuk; Oh Myeong Hwan; Park Kwang Jun; Heo Jun Hyeok; Lee Min Won^*

来源：Fitoterapia, 2014, 92: 188-193.

DOI：10.1016/j.fitote.2013.10.007

• Myrica rubra
• Diarylheptanoid
• Flavonoid
• Sulfate
• Inflammation
• RAW 264.7 cells

Three sulfated phenolic compounds, juglanin B (11R)-O-sulfate (1), myricetin 3%26apos;-O-sulfate (2), and ampelopsin 3%26apos;-O-sulfate (3), were isolated from the leaves of Myrica rubra. Compound 1 was a new sulfated lignan, 2 was a new sulfated flavone, and 3 was a known sulfated flavone. The structures of the new compounds (1 and 2) were determined by acid hydrolysis and spectroscopic methods, including IR, FAB-MS, 1D and 2D NMR. The inhibitory activities of compounds 1-3 and their hydrolysates (1a-3a) against LPS-induced cytokine (TNF-alpha, IL-1 beta and IL-6) production in macrophage RAW 264.7 cells were evaluated. The 2 new compounds (1 and 2) and their aglycones (1a and 2a) significantly reduced LPS-induced expression of iNOS and COX-2 proteins.

• 出版日期2014-1