Abnormal Liver Stiffness Assessed Using Transient Elastography (Fibroscan (R)) in HIV-Infected Patients without HBV/HCV Coinfection Receiving Combined Antiretroviral Treatment

作者：Han Sang Hoon; Kim Seung Up; Kim Chang Oh; Jeong Su Jin; Park Jun Yong; Choi Jun Yong; Kim Do Young; Ahn Sang Hoon; Song Young Goo; Han Kwang Hyub; Kim June Myung^*

来源：PLos One, 2013, 8(1): e52720.

DOI：10.1371/journal.pone.0052720

Background and Aims: Liver stiffness measurement (LSM) using transient elastography (Fibroscan (R)) can identify individuals with potential underlying liver disease. We evaluated the prevalence of abnormal LSM values as assessed using LSM and its predictors in HIV-infected asymptomatic patients receiving combined antiretroviral treatment (cART) without HBV/HCV coinfection.
Methods: We prospectively recruited 93 patients who had consistently been undergoing cART for more than 12 months at Severance Hospital in Seoul, Republic of Korea, from June to December 2010. LSM values >5.3 kPa were defined as abnormal.
Results: Thirty-nine (41.9%) had abnormal LSM values. On multivariate correlation analysis, the cumulative duration of boosted and unboosted protease inhibitors (PIs) were the independent factors which showed a negative and positive correlation to LSM values, respectively (beta = -0.234, P = 0.023 and beta = 0.430, P<0.001). In multivariate logistic regression analysis, the cumulative exposure duration of boosted-PIs and gamma-glutamyltranspeptidase levels were selected as the independent predictors which showed a negative and positive correlation with abnormal LSM values, respectively (odds ratio [OR], 0.941; 95% confidence interval [CI], 0.889-0.997; P = 0.039 and OR, 1.032; 95% CI, 1.004-1.060; P = 0.023).
Conclusion: The high percentage of HIV-infected asymptomatic patients receiving cART without HBV/HCV coinfection had abnormal LSM values. The cumulative exposure duration of boosted-PIs and gamma-GT level were independent predictors which showed a negative and positive correlation with abnormal LSM values, respectively.

• 出版日期2013-1-3