A New 2H-Pyran-2-One Derivative and Anti-inflammatory Constituents of Alpinia zerumbet

作者：Chen Jih Jung^*; Liao Hsiang Ruei; Chen Keh Shaw; Cheng Ming Jen^*; Shu Chih Wen; Sung Ping Jyun; Lim Yun Ping; Wang Tai Chi; Kuo Wen Lung

来源：Chemistry of Natural Compounds, 2017, 53(1): 40-43.

DOI：10.1007/s10600-017-1906-6

• Alpinia zerumbet
• Zingiberaceae
• 4-hydroxy-6-(4-methoxyphenethyl)-2H-pyran-2-one

A new 2H-pyran-2-one derivative, 4-hydroxy-6-(4-methoxyphenethyl)-2H-pyran-2-one (1), together with four known compounds, 5,6-dehydrokawain (2), dihydro-5,6-dehydrokawain (3), (E)-labda-8(17),12-diene-15,16-dial (4), and quercetin (5) were isolated from the rhizomes of Alpinia zerumbet. (E)-Labda-8(17),12-diene-15,16-dial (4) and quercetin (5) exhibited potent inhibition, with IC50 values of 3.18 +/- 1.13 and 1.17 +/- 0.13 mu g/mL, respectively, against formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)-induced superoxide anion (O (2) (-) ) generation.

• 出版日期2017-1
• 单位中国医科大学; 长春大学