Determination of Ascorbic Acid in Tablet Dosage Forms and Some Fruit Juices by DPV

作者：Yilmaz Selehattin^*; Sadikoglu Murat; Saglikoglu Gulsen; Yagmur Sultan; Askin Gokce

来源：International Journal of Electrochemical Science, 2008, 3(12): 1534-1542.

DOI：10.1016/s1452-3981(23)15537-4

• Ascorbic acid
• Voltammetry
• Tablet dosage forms
• Fruit juices

Ascorbic acid, a water-soluble vitamin, is the most common electroactive biological compound found in some fruit species. The electrochemical oxidation of ascorbic acid was investigated at glassy carbon electrode in various aqueous solutions in the pH range of 0.64-10.15 (in Britton-Robinson, acetate, phosphate buffers and 0.5 mol L(-1) sulphuric acid solutions) by cyclic (CV) and differential pulse (DPV) voltammetry. For the quantitative purposes, a very well-resolved diffusion-controlled voltammetric peak was obtained in 0.2 mol L(-1) acetate buffer (pH 3.49) at 0.342 V by DPV technique. The linear response was obtained in the concentration range of 6x10(-6)-8x10(-4) mol L(-1) with a detection limit (LOD) of 5.17x10(-7) and quantitative limit (LOQ) of 1.72x10(-6) mol L(-1). Ascorbic acid in pharmaceutical dosage forms and some fruit juices were determined by DPV. The reliability of the proposed voltammetric technique was established by recovery studies.

• 出版日期2008-12