Amphiphilic Imbalance and Stabilization of Block Copolymer Micelles on-Demand through Combinational Photo-Cleavage and Photo-Crosslinking

作者：Zhang, Xuan; Wang, Youpeng; Li, Guo; Liu, Zhaotie; Liu, Zhongwen; Jiang, Jinqiang^*

来源：Macromolecular Rapid Communications, 2017, 38(1): 1600543.

DOI：10.1002/marc.201600543

• amphiphilic imbalance
• micellar stability
• photolysis
• photo-crosslinking
• polymer micelles

An amphiphilic block copolymer of poly(ethylene oxide)-b-poly((N-methacryloxy phthalimide)co-( 7-(4-vinyl-benzyloxyl)-4-methylcoumarin)) (PEO45-b-P(MAPI(36)-co-VBC4)) is designed to improve the micellar stability during the photo-triggered release of hydrophobic cargoes. Analysis of absorption and emission spectra, solution transmittance, dynamic light scattering, and transmission electron microscopy supports that polymer micelles of PEO45-b-P(MAPI(36)-co-VBC4) upon the combinational irradiation of 365 and 254 nm light can be solubilized through the photolysis of phthalimide esters and simultaneously crosslinked via the partially reversible photo-dimerization of coumarins. The photo-triggered release experiment shows that the leakage of doxorubicin molecules from crosslinked micelles can be predictably regulated by controlling the irradiation time of 365 and 254 nm light.

• 出版日期2017-1
• 单位陕西师范大学