Annulation of beta-Enaminonitriles with Alkynes via Rh-III-Catalyzed C-H Activation: Direct Access to Highly Substituted 1-Naphthylamines and Naphtho[1,8-bc]pyridines

作者：Wang, Haili; Xu, Hong; Li, Bin^*; Wang, Baiquan

来源：Organic Letters, 2018, 20(18): 5640-5643.

DOI：10.1021/acs.orglett.8b02341

• CASCADE OXIDATIVE ANNULATION
• INTERNAL ALKYNES
• BOND ACTIVATION
• N BOND
• PYRROLE SYNTHESIS
• INDOLE SYNTHESIS
• DIAZO-COMPOUNDS
• ARYL KETONES
• FUNCTIONALIZATION
• CYCLIZATION

A Cp*Rh-III-catalyzed oxidative annulation of beta-enaminonitriles with alkynes was reported to achieve selective synthesis of polysubstituted 1-naphthylamines and naphtho[1,8-bc]pyridines via multiple C-H activations. Assisted by a naphthylamine NH2 group, 1-naphthylamines were also readily cyclized to produce naphtho[1,8-bc]pyridines. In addition, the obtained naphtho[1,8-bc]pyridine derivatives exhibit intense fluorescence in the solid state.

• 出版日期2018-9-21
• 单位中国科学院; 金属有机化学国家重点实验室; 元素有机化学国家重点实验室; 南开大学