Health benefits of high-density lipoproteins in preventing cardiovascular diseases

作者：Berrougui Hicham^*; Momo Claudia N; Khalil Abdelouahed

来源：Journal of Clinical Lipidology, 2012, 6(6): 524-533.

DOI：10.1016/j.jacl.2012.04.004

• Atherogenesis
• Cardiovascular diseases
• Cholesterol efflux
• HDL
• Paraoxonase 1
• Reverse cholesterol transport

Plasma levels of high-density lipoprotein (HDL) are strongly and inversely correlated with atherosclerotic cardiovascular diseases. However, it is becoming clear that a functional HDL is a more desirable target than simply increasing HDL-cholesterol levels. The best known antiatherogenic function of HDL particles relates to their ability to promote reverse cholesterol transport from peripheral cells. However, HDL also possesses antioxidant, anti-inflammatory, and antithrombotic effects. This review focuses on the state of knowledge regarding assays of HDL heterogeneity and function and their relationship to cardiovascular diseases.

• 出版日期2012-12