Comparing Arterial Function Parameters for the Prediction of Coronary Heart Disease Events The Multi-Ethnic Study of Atherosclerosis (MESA)

作者：Hom Elizabeth K^*; Duprez Daniel A; Jacobs David R Jr; Bluemke David A; Brumback Lyndia C; Polak Joseph F; Peralta Carmen A; Greenland Philip; Magzamen Sheryl L; Lima Joao A C; Redheuil Alban; Herrington David M; Stein James H; Vaidya Dhananjay; Ouyang Pamela; Kaufman Joel D

来源：American Journal of Epidemiology, 2016, 184(12): 894-901.

DOI：10.1093/aje/kww113

• arteries
• coronary disease
• vascular stiffness

Arterial dysfunction has been linked to decline in cardiac function and increased risk of cardiovascular disease events. We calculated the value of arterial function, measured at baseline (2000-2002), in predicting time to first coronary heart disease (CHD) event (median follow-up, 10.2 years) among participants in the MultiEthnic Study of Atherosclerosis (MESA). Measures included the following: C-1 and C-2, derived from diastolic pulse contour analysis from the radial artery blood pressure waveform obtained by tonometry (n = 6,336); carotid distensibility and Young's elastic modulus at the carotid artery, derived from carotid artery ultrasonography (n = 6,531 and 6,528); and aortic distensibility, measured using cardiac magnetic resonance imaging (n = 3,677). After adjustment, the hazard ratio for a CHD event per standard-deviation increment in arterial function was 0.97 (95% confidence interval (CI): 0.86, 1.10) for C1, 0.73 (95% CI: 0.63, 0.86) for C-2, 0.98 (95% CI: 0.86, 1.11) for carotid distensibility, 0.99 (95% CI: 0.90, 1.09) for Young's modulus, and 0.90 (95% CI: 0.74, 1.10) for aortic distensibility. We examined the area under the receiver operating characteristic curve for the model with full adjustment plus the addition of each measure individually. C-2 provided additional discrimination for the prediction of CHD (area under the curve = 0.736 vs. 0.743; P = 0.04). Lower C-2 was associated with a higher risk of future CHD events.

• 出版日期2016-12-15
• 单位西北大学; NIH