Soy-derived Isoflavones Treatment in Children with Hypercholesterolemia: A Pilot Study

作者：Zung Amnon^*; Shachar Sabina; Zadik Zvi; Kerem Zohar

来源：Journal of Pediatric Endocrinology & Metabolism, 2010, 23(1-2): 133-141.

• isoflavones
• hypercholesterolemia
• soy
• children

Aims: To evaluate for the first time in children the effect of soy-derived isoflavones on lipid profile and insulin resistance.
Methods: Twelve hypercholesterolemic children (8 females) aged 5.3 to 11.2 years have completed a prospective, controlled pilot study. After a low-fat diet for 12 weeks, children who maintained high cholesterol and low-density lipoprotein-cholesterol (LDL-C) levels were randomly assigned to three intervention periods of either placebo or low and high dose isoflavone (16 or 48 mg) consumption, each period lasting 8 weeks.
Results: The diet significantly reduced LDL-C and apolipoprotein B (Apo B) levels. However, isoflavones had no effect on cholesterol, LDLC, high-density lipoprotein-cholesterol (HDL-C), triglycerides, lipoprotein (a), Apo B, or insulin resistance, at either low or high doses. Isoflavones had no effect on sex hormones, gonadotropins, sex-hormone binding globulin and thyroid hormones.
Conclusions: The results of this pilot study do not suggest a beneficial role of an isoflavone-enriched diet in children with hypercholesterolemia.

• 出版日期2010-2