High expression of miR-214 is associated with a worse disease-specific survival of the triple-negative breast cancer patients

作者：Kalniete Dagnija^*; Nakazawa Miklasevica Miki; Strumfa Ilze; Abolins Arnis; Irmejs Arvids; Gardovskis Janis; Miklasevics Edvins

来源：Hereditary Cancer in Clinical Practice, 2015, 13(1): 7.

DOI：10.1186/s13053-015-0028-z

• MiRNA expressionm
• Hereditary and sporadic breast cancers
• Triple-negative subtype

Background: Hereditary triple-negative breast cancer patients have better recurrence-free survival than triplenegative sporadic ones. High expression of some of the miRNAs is related to worse overall and disease-free survival of triple-negative breast cancer patients. The attempt to associate expression level of some miRNA in triple-negative hereditary and sporadic breast cancers to disease specific survival was performed in this study.
Material and methods: Study group was made of 18 triple-negative breast cancer patients harboring the BRCA1 gene mutations and 32 triple-negative sporadic breast cancer patients. Quantitative amount of mir-10b, mir-21, mir-29a, mir-31, and mir-214 by real-time PCR was assessed. The disease-specific survival in relation of high and low levels of some of the miRNAs was analyzed using Log-rank (Mantel-Cox) test.
Results: MiR-214 showed significantly higher expression level in sporadic tissues than in hereditary ones (p = 0.0005). Triple-negative breast cancer patients with high level of miR-214 showed significantly worse disease-specific survival than patients with low level (p = 0.0314).
Conclusions: Our finding suggests that miR-214 possibly could be used as a potential prognostic biomarker for triple-negative breast cancer patients.

• 出版日期2015-2-8