科研之友
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摘要
The neuroprotective effects of Panax ginseng were extensively studied. However, the therapeutic role of Panax ginseng in rat model of Parkinson's disease (PD) has not been studied enough. In the present study, rats were divided into three groups; control, rat model of PD induced by intrastriatal injection of rotenone and rat model of PD treated daily with Panax ginseng extract (100 mg/kg for 2 weeks). Forelimb wire hanging and the traction tests scored a significant decrease in PD model rats. In ginseng extract-treated group, these behavioral parameters changed to non significant values from the control rats. In the midbrain of rat model, a state of oxidative stress was observed as indicated from the significant increase in lipid peroxidation, nitric oxide and tumor necrosis factor-a and the decrease in reduced glutathione in comparison to control. This was accompanied by a significant decrease in dopamine and a significant increase in acetylcholinesterase activity. In the striatum, an increase in lipid peroxidation and a decrease in nitric oxide, dopamine content and acetylcholinesterase were recorded. Panax ginseng treatment improved all the midbrain and striatal changes induced by rotenone except nitric oxide. However, this improvement was partial since the measured parameters in ginseng-treated group were not significant from the rat model of PD except tumor necrosis factor-a. From the present findings, it could be concluded that Panax ginseng extract administration for 2 weeks showed a partial ameliorative effect against the rat model of PD induced by the intrastriatal injection of rotenone.
- 出版日期2016
