Microbial Flora Drives Interleukin 22 Production in Intestinal NKp46(+) Cells that Provide Innate Mucosal Immune Defense

作者：Satoh Takayama Naoko; Vosshenrich Christian A J; Lesjean Pottier Sarah; Sawa Shinichiro; Lochner Matthias; Rattis Frederique; Mention Jean Jacques; Thiam Kader; Cerf Bensussan Nadine; Mandelboim Ofer; Eberl Gerard; Di Santo James P^*

来源：Immunity, 2008, 29(6): 958-970.

DOI：10.1016/j.immuni.2008.11.001

Natural killer (NK) cells are innate lymphocytes with spontaneous antitumor activity, and they produce interferon-gamma (IFN-gamma) that primes immune responses. Whereas T helper cell subsets differentiate from naive T cells via specific transcription factors, evidence for NK cell diversification is limited. In this report, we characterized intestinal lymphocytes expressing the NK cell natural cytotoxicity receptor NKp46. Gut NKp46(+) cells were distinguished from classical NK cells by limited IFN-gamma production and absence of perforin, whereas several subsets expressed the nuclear hormone receptor retinoic acid receptor-related orphan receptor t (ROR gamma t) and interleukin-22 (IL-22). Intestinal NKp46(+)IL-22(+) cells were generated via a local process that was conditioned by commensal bacteria and required ROR gamma t. Mice lacking IL-22-producing NKp46(+) cells showed heightened susceptibility to the pathogen Citrobacter rodentium, consistent with a role for intestinal NKp46(+) cells in immune protection. ROR gamma t-driven diversification of intestinal NKp46(+) cells thereby specifies an innate cellular defense mechanism that operates at mucosal surfaces.

• 出版日期2008-12-19