Microwave assisted synthesis of substituted (Z)-2-{[1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl]methylene}benzofuran- 3(2H)-ones and their antimicrobial activity

作者：Ashok D^*; Ziauddin M; Lakshmi B Vijaya; Sarasija M

来源：Russian Journal of General Chemistry, 2016, 86(7): 1753-1757.

DOI：10.1134/S1070363216070355

• antimicrobial activity
• aurone
• microwave irradiation
• pyrazole

Aurones, pyrazole and thiophene scaffolds are known for their potential antimicrobial activity. Herein, we have synthesized hybrid compounds containing three substituted (Z)-2-{[1-phenyl-3-(thiophen-2-yl)- 1H-pyrazol-4-yl]methylene}benzofuran-3(2H)-ones that had been produced from substituted (E)-1-(2-hydroxyphenyl)- 3-[1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl]prop-2-en-1-ones in high yields. All synthesized compounds were tested in vitro for their antimicrobial activity. Several of those demonstrated promising activity against some fungal and bacterial strains.

• 出版日期2016-7