Association Between Tryptophan Hydroxylase-2 Gene and Late-Onset Depression

作者：Pereira Patricia de Araujo^*; Romano Silva Marco Aurelio; Camargos Bicalho Maria Aparecida; De Marco Luiz; Correa Humberto; de Campos Simone Becho; de Moraes Edgar Nunes; de Lima Torres Karen Cecilia; de Souza Bruno Rezende; de Miranda Debora Marques

来源：American Journal of Geriatric Psychiatry, 2011, 19(9): 825-829.

DOI：10.1097/JGP.0b013e31820eeb21

• Tryptophan hydroxylase-2 (TPH2)
• single-nucleotide polymorphism (SNP)
• late-onset depression (LOD)

The aim of this study was to examine the association between polymorphisms (SNP) in the tryptophan hydroxylase-2 (TPH2) gene and late-onset depression (LOD) in the Brazilian population. Methods: We genotyped 8 tag SNPs in the TPH2 gene in 84 outpatients with LOD and 79 individuals belonging to the comparison group to investigate an association between the TPH2 gene and LOD. Results: Our findings suggested an association between tag SNP rs4565946 heterozygous C/T (p = 0.034; chi(2) = 6.7; df = 2) and decreased risk of LOD. The tag SNP rs11179000 ancestral homozygous A/A (p = 0.025; chi(2) = 7.3; df = 2) and increase risk of LOD and allelic association of ancestral allele A and increase risk of LOD was demonstrated (p = 0.005; chi(2) = 7.8; df = 1). Conclusion: We found the statistically significant association between two tag SNPs and LOD. Our results support the hypothesis that the TPH2 gene is associated with LOD. (Am J Geriatr Psychiatry 2011; 19:825-829)

• 出版日期2011-9