Association of single nucleotide polymorphisms in ADAM12 gene with susceptibility to knee osteoarthritis: a case-control study in a Chinese Han population

作者：Lou, Suliang; Zhao, Zhifang; Qian, Jinqian; Zhao, Kefeng; Wang, Ran^*

来源：International Journal of Clinical and Experimental Pathology, 2014, 7(8): 5154-5159.

• Single-nucleotide polymorphisms
• ADAM12 gene
• osteoarthritis
• susceptibility

Objective: Genetic factors play an important role in osteoarthritis (OA) etiology and ADAM12 gene polymorphisms may be involved. This study tried to examine the single-nucleotide polymorphisms (SNPs) of ADAM12 for their association with knee OA susceptibility in a Chinese Han population. Methods: The rs3740199, rs1871054, rs1278279, and rs1044122 SNPs in ADAM12 gene were genotyped in 152 subjects who were diagnosed as knee osteoarthritis and in 179 healthy controls. Results: Rs1871054 was found to be significantly associated with increased risk of OA (C vs. T, OR 1.802 (1.308 to 2.483), P < 0.0001) after adjustment of age, gender, and BMI. For other SNPs, no statistically significant associations with OA were found. Conclusion: In conclusion, our data demonstrated the ADAM12 rs1871054 variant was found to be significantly associated with increased OA susceptibility in a Chinese Han population.

• 出版日期2014
• 单位中国人民解放军第一一七医院