科研之友
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摘要
A population genetic model is used to describe dynamical aspects of chromosomal abberations observed in M-FISH experiments. Linear differential equations model the evolution of relative frequencies of mutations. The unknown parameters involved are estimated by maximum likelihood methods. We propose a scoring system to select the most important mutations. In order to reduce the number of parameters and computation time, only the highest ranked mutations are considered. First applications to M-FISH data show rather promising results.
- 出版日期2008-3
- 单位河北医科大学
