科研之友
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摘要
Protection of chromosomal ends from erroneous recognition as double-strand breaks (DSBs) is critical for maintaining genome integrity. Unprotected ends can activate DNA repair pathways leading to catastrophic fusions or rearrangements of chromosomes. A study in The EMBO Journal identifies Uls1 as a new player in this end-protection process, utilizing SUMO and ubiquitin modifications to prevent chromosomal fusions by clearing a polysumoylated form of Rap1.
- 出版日期2013-3-20
