Differentially expressed lncRNAs and mRNAs identified by microarray analysis in GBS patients vs healthy controls

作者：Xu, Jing; Gao, Chao; Zhang, Fang; Ma, Xiaofeng; Peng, Xiaolin; Zhang, Rongxin; Kong, Dexin; Simard, Alain R.; Hao, Junwei^*

来源：Scientific Reports, 2016, 6(1): 21819.

DOI：10.1038/srep21819

• LONG NONCODING RNAS
• AUTOANTIBODIES
• PROTEASOME
• ALPHA

The aim of our present study was to determine whether message RNAs (mRNAs) and long noncoding RNAs (lncRNAs) are expressed differentially in patients with Guillain-Barre syndrome (GBS) compared with healthy controls. The mRNA and lncRNA profiles of GBS patients and healthy controls were generated by using microarray analysis. From microarray analysis, we listed 310 mRNAs and 114 lncRNAs with the mRMR software classed into two sample groups, GBS patients and healthy controls. KEGG mapping demonstrated that the top seven signal pathways may play important roles in GBS development. Several GO terms, such as cytosol, cellular macromolecular complex assembly, cell cycle, ligase activity, protein catabolic process, etc., were enriched in gene lists, suggesting a potential correlation with GBS development. Co-expression network analysis indicated that 113 lncRNAs and 303 mRNAs were included in the co-expression network. Our present study showed that these differentially expressed mRNAs and lncRNAs may play important roles in GBS development, which provides basic information for defining the mechanism(s) that promote GBS.

• 出版日期2016-2-22
• 单位天津市环湖医院; 天津医科大学