A facile synthesis of 3,4-dihydropyrimidinones/thiones and novel N-dihydro pyrimidinone-decahydroacridine-1,8-diones catalyzed by cellulose sulfuric acid

作者：Rajack Abdul^*; Yuvaraju K; Praveen Ch; Murthy Y L N

来源：Journal of Molecular Catalysis A: Chemical , 2013, 370: 197-204.

DOI：10.1016/j.molcata.2013.01.003

• New N-dihydro pyrimidinone-decahydroacridine-1,8-diones
• Cellulose sulphuric acid
• Biginelli reaction
• Hantzsch reaction
• Recyclable catalyst

A new and efficient method has been developed for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones (DHPMs) through Biginelli reaction in aqueous media. Furthermore, a new series of N-dihydro pyrimidinone-decahydroacridine-1,8-diones (8a-m) have been synthesized by the Hantzsch reaction of 5-Ethoxycarbony1-4-(4-aminophenyl)-6-methyl-3,4-dihydropyrimidine-2(1H)-one 5 (DHPM), with dimedone and aromatic aldehyde in acetonitrile under reflux conditions. All the products in both reactions obtained in good to excellent yields by proceeding through a simple and efficient procedure employing cellulose sulfuric acid (CSA) as a recyclable solid acid catalyst. All the newly synthesized compounds structure has been established by advanced spectroscopic data.

• 出版日期2013-4