A convenient approach towards boron cluster modifications with adenosine and 2 '-deoxyadenosine

作者：Semioshkin Andrey^*; Bregadze Vladimir; Godovikov Ivan; Ilinova Anna; Lesnikowski Zbigniew J; Lobanova Irina

来源：Journal of Organometallic Chemistry, 2011, 696(23): 3750-3755.

DOI：10.1016/j.jorganchem.2011.08.031

• closo-Dodecaborate
• Cobalt-bis-dicarbollide
• Oxonium derivatives
• Nucleosides
• Adenosine
• 2 '-Deoxyadenosine

New 2'-deoxyadenosine and adenosoine modifications: 8-[(2-dimethylaminoethyl)amino]-2'-deoxyadenosine and 8-[(2-dimethylaminoethyl)amino]adenosine were prepared and their reactivity towards cyclic oxonium adducts of closo-dodecaborate and cobalt-bis-dicarbollide was studied. The cleavage reactions of clusters oxonium rings by N,N-dimethylanio group of modified nucleosides led to the first [B12H12](2-) and new [Co(C2B9H11)(2)](-) conjugates with adenosine and 2'-deoxyadenosine respectively. The proposed methodology provides a convenient route for the synthesis of libraries of boron cluster modified adenosine and 2'-deoxyadenosine derivatives for biological screening.

• 出版日期2011-11-15
• 单位河北医科大学