Association analysis of two candidate polymorphisms in the Tumour Necrosis Factor-alpha gene with osteoarthritis in a Chinese population

作者：Ji, Bin; Shi, Jixiang; Cheng, Xiangyu; Zhou, Junjie; Zhou, Qiang; Cao, Chengfu^*; Pang, Jinhui

来源：International Orthopaedics, 2013, 37(10): 2061-2063.

DOI：10.1007/s00264-013-1931-4

• SINGLE-NUCLEOTIDE POLYMORPHISMS
• CLASS II/III REGION
• KNEE OSTEOARTHRITIS
• PROMOTER
• SUSCEPTIBILITY

Purpose The purpose of this study was to investigate the possible association between single nucleotide polymorphisms (SNPs) rs1800629 (TNF-alpha -308) and rs361525 (TNF-alpha -238) of the tumour necrosis factor (TNF)-alpha gene and susceptibility to osteoarthritis (OA) in the Han Chinese population.
Methods The TNF-alpha -308 and -238 genotypes were determined by TaqMan assay in 200 OA cases and 305 controls. Odds ratios (ORs) for OA and 95 % confidence intervals (CIs) from unconditional logistic regression models were used to evaluate relative risks.
Results The frequencies of the allele 'A' of rs1800629 were 16 % and 8.85 % in OA cases and in controls, respectively, and thus the -308A allele had a 1.9612-fold (95 % CI = 1.3323-2.8869, P < 0.001) increased risk for OA as compared to the -308G allele. However, no significant differences were found in the genotype and allele frequencies for rs361525 between OA and HC groups.
Conclusions In the Han Chinese population, the allele 'A' of TNF-alpha -308 may increase the risk for OA, whereas TNF-alpha -238 polymorphisms do not play a role in OA patients.

• 出版日期2013-10
• 单位上海中医药大学