A mild copper-mediated Glaser-type coupling reaction under the novel CuI/NBS/DIPEA promoting system

作者：Li Lingjun; Wang Jiuxia; Zhang Guisheng^*; Liu Qingfeng

来源：Tetrahedron Letters, 2009, 50(28): 4033-4036.

DOI：10.1016/j.tetlet.2009.04.065

A simple copper promoting system CuI/NBS/DIPEA was first found to efficiently promote Glaser coupling reaction under ambient temperature. The alkynes with sensitive groups such as acetal and ketal, TBDMS, ester and amide could react smoothly to afford the functionalized 1,3-diynes under the CuI/NBS/DIPEA promoting system in good yields. And the successful application of the Cul/NBS/DIPEA promoting system in sugar and amino acid-building blocks indicated the potential of this method in the construction of designed sugar and peptide biomolecules.

• 出版日期2009-7-15
• 单位河南师范大学