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摘要
This article investigates the association of the time interval between the diagnostic dose and ablation with the stunning effect, when a 74MBq I-131 pretherapy scanning was performed on patients with differentiated thyroid carcinoma (DTC); the patients who were diagnosed as DTC and would be performed radioiodine (RAI) ablation of thyroid remnants or metastases were recruited during January 2011 and May 2012 in our hospital.Thirty-seven patients with DTC who had the RAI ablation of thyroid remnants or metastases for the first time were recruited. All the patients received a dose of 1850 to 7400MBq of I-131 for ablation and a diagnostic scan was performed 24 hours after the administration of 74MBq I-131 before ablation. A posttherapy scan was performed 2 to 7 days after the ablation. The patients were broken down into 3 groups (G1, G2, and G3) according to the interval time between the diagnostic dose and therapy (1-3, 4-7, and >7 days). The fractional concentrations of I-131 in remnants or functional metastases were quantified and expressed as therapeutic/diagnostic (Rx/Dx). The level of significance was set at 0.05.Sixty-seven foci were found both on pretherapy and posttherapy scans, the mean ratio of Rx/Dx was 0.430.29, and the ratio of 49 foci (73.13%) was <0.6. The ratios in G1, G2, and G3 were 0.46 +/- 0.29, 0.29 +/- 0.18, and 0.55 +/- 0.33, respectively. The differences between G1 and G2, and G2 and G3 were statistically significant (t=2.40, P=0.021 and t=3.28, P=0.002), whereas the difference between G1 and G3 was not significant (t=1.01, P=0.319).By a diagnostic scan of 74MBq I-131, stunning prominently occurs with a time of 4 to 7 days between the diagnostic dose and ablation. We recommend that for less stunning effect, RAI ablation should be performed within 3 days or postponed until 1 week after the diagnostic dose administrated.
- 出版日期2015-8
- 单位中国医科大学
