Size-Dependent Endocytosis of Nanoparticles

作者:Zhang Sulin*; Li Ju; Lykotrafitis George; Bao Gong; Suresh Subra
来源:Advanced Materials, 2009, 21(4): 419-+.
DOI:10.1002/adma.200801393

摘要

The cellular uptake of nanoparticles by living cells is predicted to be strongly size-dependent, according the thermodynamic analysis, and an optimal particle radius of similar to 25-30 nm at which the cellular uptake reaches a maximum of several thousand is shown to exist. The theoretical prediction provides valuable guidance for the rational design of nanoparticle-based drug-delivery systems.

  • 出版日期2009-1-26