Anti-Inflammatory Thioredoxin Family Proteins for Medicare, Healthcare and Aging Care

作者：Yodoi Junji^*; Matsuo Yoshiyuki; Tian Hai; Masutani Hiroshi; Inamoto Takashi

来源：Nutrients, 2017, 9(10): 1081.

DOI：10.3390/nu9101081

• inflammation
• oxidative stress
• redox
• thioredoxin
• thioredoxin-interacting protein

Human thioredoxin (TRX) is a 12-kDa protein with redox-active dithiol in the active site -Cys-Gly-Pro-Cys-, which is induced by biological stress due to oxidative damage, metabolic dysfunction, chemicals, infection/inflammation, irradiation, or hypoxia/ischemia-reperfusion. Our research has demonstrated that exogenous TRX is effective in a wide variety of inflammatory diseases, including viral pneumonia, acute lung injury, gastric injury, and dermatitis, as well as in the prevention and amelioration of food allergies. Preclinical and clinical studies using recombinant TRX (rhTRX) are now underway. We have also identified substances that induce the expression of TRX in the body, in vegetables and other plant ingredients. Skincare products are being developed that take advantage of the anti-inflammatory and anti-allergic action of TRX. Furthermore, we are currently engaged in the highly efficient production of pure rhTRX in several plants, such as lettuce, grain and rice.

• 出版日期2017-10
• 单位绍兴文理学院