Limited HIV Infection of Central Memory and Stem Cell Memory CD4+ T Cells Is Associated with Lack of Progression in Viremic Individuals

作者：Klatt Nichole R^*; Bosinger Steven E; Peck Melicent; Richert Spuhler Laura E; Heigele Anke; Gile Jillian P; Patel Nirav; Taaffe Jessica; Julg Boris; Camerini David; Torti Carlo; Martin Jeffrey N; Deeks Steven G; Sinclair Elizabeth; Hecht Frederick M; Lederman Michael M; Paiardini Mirko; Kirchhoff Frank; Brenchley Jason M; Hunt Peter W; Silvestri Guido

来源：PLoS Pathogens, 2014, 10(8): e1004345.

DOI：10.1371/journal.ppat.1004345

A rare subset of HIV-infected individuals, designated viremic non-progressors (VNP), remain asymptomatic and maintain normal levels of CD4+ T-cells despite persistently high viremia. To identify mechanisms potentially responsible for the VNP phenotype, we compared VNPs (average %26gt;9 years of HIV infection) to HIV-infected individuals who have similar CD4+ T-cell counts and viral load, but who are likely to progress if left untreated (%26quot;putative progressors%26apos;%26apos;, PP), thus avoiding the confounding effect of differences related to substantial CD4+ T cell depletion. We found that VNPs, compared to PPs, had preserved levels of CD4+ stem cell memory cells (TSCM (p%26lt;0.0001), which was associated with decreased HIV infection of these cells in VNPs (r = -0.649, p = 0.019). In addition, VNPs had decreased HIV infection in CD4+ central memory (T-CM) cells (p = 0.035), and the total number of TCM cells was associated with increased proliferation of memory CD4+ T cells (r = 0.733, p = 0.01). Our results suggest that, in HIV-infected VNPs, decreased infection of CD4+ T-CM and T-SCM, cells are involved in preservation of CD4+ T cell homeostasis and lack of disease progression despite high viremia.

• 出版日期2014-8
• 单位NIH; MIT