Are MicroRNAs Key to Developing Biomarkers for Cutaneous T-Cell Lymphoma?

作者:Martinez Escala Maria Estela; Choi Jaehyuk*
来源:Journal of Investigative Dermatology, 2018, 138(9): 1906-1908.
DOI:10.1016/j.jid.2018.04.012

摘要

MicroRNAs are noncoding molecules that induce epigenetic modulation, and they have been involved in tumorigenesis of solid and hematologic malignancies, including cutaneous T-cell lymphoma. MicroRNAs appear to play a role in cutaneous T-cell lymphoma pathogenesis and in disease progression. We comment on recent efforts to develop microRNA classifiers that improve cutaneous T-cell lymphoma diagnosis and predict disease course.