Long-term Low-molecular-weight Heparin Therapy during Pregnancy: Is There a Bone Risk?

作者：Khalifa Pierre^*; Marie Scemama Lydia

来源：Therapie, 2013, 68(1): 37-42.

DOI：10.2515/therapie/2013008

• long term heparin
• pregnancy
• osteoporosis

Long-term Low-molecular-weight Heparin Therapy during Pregnancy: Is There a Bone Risk? Unfractionated heparin (UFH) and low-molecular-weight heparins (LMWH) are broadly used for the thromboprophylaxis during pregnancy. Long-term heparin therapy has raised concern about the risk of bone loss and osteoporotic fractures while pregnancy by itself favors osteoporosis. Experimental studies show a comparable effect of UFH and LMWH on bone formation while UFH has a more marked effect on bone resorption. Available clinical studies do not provide evidence of a difference between UFH and LMWH or among different LMWH on the bone risk. However, clinical studies show that bone loss observed with LMWH is not different from the physiological loss related to pregnancy, and osteoporotic fractures are associated with comorbidities or osteoporosis risk factors. LMWH represent the preferred alternative for thromboprophylaxis during pregnancy.

• 出版日期2013-2