Association of immune system gene polymorphisms with quantitative traits pathogenetically important for chronic virus hepatitis

作者：Goncharova I A^*; Beloborodova E V; Freidin M B; Beloborodov E I; Chernogoruk G E; Puzyrev V P

来源：Molecular Biology, 2008, 42(2): 213-216.

DOI：10.1134/S0026893308020064

• chronic virus hepatitis
• genetics of infectious diseases
• genetic polymorphism
• cytokine genes

The IL4 C(-590)T, IL4RA Ile50Val, and TNF G(-308)A polymorphisms were tested for association with quantitative traits important for chronic virus hepatitis, including the levels of IL4, IL10, IL12, TNF-alpha, fibronectin, collagenase, the proteinase inhibitor, macroglobulin, and free and protein-bound (PBO) oxyproline. Allele A of the TNF G(-308)A polymorphism was associated with a lower TNF-alpha production by mononuclear cells, a higher production of IL4 and IL12, and a lower PBO level. The genotype CT of the IL4 C(-590)T polymorphism was associated with a high PBO level.

• 出版日期2008-4
• 单位河北医科大学