Iptakalim alleviated the increase of extracellular dopamine and glutamate induced by 1-methyl-4-phenylpyridinium ion in rat striatum

作者：Yang, Yan-Jing; Wang, Qing-Min; Hu, Li-Fang; Sun, Xiu-Lan; Ding, Jian-Hua; Hu, Gang^*

来源：Neuroscience Letters, 2006, 404(1-2): 187-190.

DOI：10.1016/j.neulet.2006.05.042

• iptakalim
• 1-methyl-4-phenylpyridinium ion (MPP+)
• dopamine
• glutamate
• microdialysis

The present study examined the effect of iptakalim (Ipt), a novel ATP-sensitive potassium (K-ATP) channel opener (KCO), on 1-methyl-4-phenylpyridinium ion (MPP+)-induced dopamine (DA) and glutamate efflux in extracellular fluid of rat striatum, using microdialysis technique. Rats were implanted guide cannula in the striatum and artificial cerebrospinal fluid was infused through a microdialysis probe to detect the level of DA and glutamate in the striatum. MPP+ significantly enhanced the extracellular levels of DA and its metabolites, DOPAC and HVA, as well as glutamate. Application of 1pt (1, 10, 100 mu M) concentration-dependently suppressed DA and its metabolites efflux induced by MPP+. Concomitantly, Ipt reduced the increase of extracellular glutamate induced by MPP+. These results suggest that Ipt can regulate DA and glutamate efflux induced by MPP+ in rat striatum.

• 出版日期2006-8-14
• 单位南京医科大学