Antiherpetic activity of an Agaricus brasiliensis polysaccharide, its sulfated derivative and fractions

作者：Yamamoto Kristie Aimi; Faccin Galhardi Ligia Carla; Rincao Vinicius Pires; Soares Sandra de Aguiar; Pinto Vieira Icaro Gusmao; Pontes Silva Ricardo Nagila Maria; Nozawa Carlos; Carvalho Linhares Rosa Elisa

来源：International Journal of Biological Macromolecules, 2013, 52: 9-13.

DOI：10.1016/j.ijbiomac.2012.09.029

• Agaricus brasiliensis
• Antiviral
• Herpes simplex virus
• Bovine herpesvirus

Agaricus brasiliensis is an edible mushroom, traditionally used for the treatment of several diseases. In this paper, a polysaccharide (PLS) from A. brasiliensis, its carboxymethylated (CPLS) and sulfated (SPLS) derivatives, as well as, fractions (F1-F3) obtained from the PLS were investigated for their effect in the replication of herpes simplex virus and bovine herpes virus in HEp-2 cell cultures. The PLS, SPLS and F3 inhibited both virus strains similarly, in a dose-dependent curve. F1, F2 and CPLS did not show significant effect even at higher concentrations. All the compounds showed neither virucidal or viral adsorption inhibition activities nor effect when cells were treated prior to infection. Our study demonstrated that the extracts of A. brasiliensis, can be promising for future antiviral drug design and its biotechnological production is economically feasible.

• 出版日期2013-1