Membrane Transport Protein ABCA1 and Type 2 Diabetes Mellitus

作者：Liu Zhen; He Zhen; Ma Wei Lie; Zhang Zhi Zhen^*

来源：Progress in Biochemistry and Biophysics, 2011, 38(9): 797-803.

DOI：10.3724/SP.J.1206.2010.00536

• ABCA1
• diabetes mellitus
• beta cell
• cholesterol

Beta cell dysfunction is a critical step in the pathogenesis of type 2 diabetes mellitus, while cellular cholesterol accumulation is an emerging mechanism for beta cell dysfunction in type 2 diabetes. Absence of the cholesterol transporter ATP-binding cassette transporter A1 (ABCA1) results in increased islet cholesterol and impaired insulin secretion, indicating that impaired cholesterol efflux leads to beta cell dysfunction.

• 出版日期2011-9
• 单位广东医科大学