Use of High-Resolution Volumetric MR Spectroscopic Imaging in Assessing Treatment Response of Glioblastoma to an HDAC Inhibitor

作者：Shim, Hyunsuk^*; Wei, Li; Holder, Chad A.; Guo, Ying; Hu, Xiaoping P.; Miller, Andrew H.; Olson, Jeffrey J.

来源：American Journal of Roentgenology, 2014, 203(2): W158-W165.

DOI：10.2214/AJR.14.12518

• epigenetic modification
• glioblastoma histone deacetylase (HDAC)
• MR spectroscopic imaging
• vorinostat

OBJECTIVE. Improved predictive imaging would enable personalization and adjustment of treatment, which are critical for patients with glioblastomain whom therapy is likely to fail. This article describes the use of MR spectroscopic imaging (MRSI) to predict early clinical and behavioral response to a therapy and an effort to develop high-resolution, volumetric MRSI to improve its clinical application. @@@ CONCLUSION. MRSI may enable quantitative analysis of brain tumor response, offering a precise tool for monitoring of patients in clinical trials.

• 出版日期2014-8