Answer to the "Comment on functional consequences of Kv1.3 ion channel rearrangement into the immunological synapse" by Stefan Bittner et al. [Immunol. Lett. 125 (Aug 15 (2)) (2009) 156-157]

作者：Hajdu Peter^*; Szilagyi Orsolya; Toth Agnes; Krasznai Zoltan; Pocsai Krisztina; Panyi Gyoergy

来源：Immunology Letters, 2010, 129(1): 47-49.

DOI：10.1016/j.imlet.2009.12.026

• Kv1.3
• TASK channels
• Immunological synapse

A critical comment to our paper on Kv1.3 channels in the immunological synapse (IS) was published, which emphasized the role of two-pore potassium channels (TASK-1 and 3) in the physiology of T lymphocytes [1]. Here we provide several lines of evidence that presence of TASK channels in the T cell line (a murine Th2 Cell line, D10) used in our experimental model cannot explain the changes in the biophysical parameters of the whole-cell current upon formation of an IS [2].

• 出版日期2010-3-10