Acute stress disrupts temporal patterns of behavioral and biochemical parameters of rats

作者：Souza Andressa^*; Detanico Bernardo Carraro; Medeiros Liciane Fernandes; de Oliveira Carla; Scarabelot Vanessa Leal; Cioato Stefania Giotti; Caumo Wolnei; Torres Iraci L S^*

来源：Biological Rhythm Research, 2018, 49(4): 521-538.

DOI：10.1080/09291016.2017.1386267

• Restraint stress
• circadian rhythm
• biomarkers
• locomotor activity
• anxiety-like behavior
• rat

This study aimed to answer these questions: (i) Can the temporal patterns of locomotor and exploratory activities and anxiety-like behavior be disrupted by a single session of stress? (ii) Can the temporal patterns of corticosterone, melatonin, and glucose be disrupted by a single session of stress and how long does the effect of stress upon their circadian rhythm? Adult male Wistar rats were exposed to restrain stress at four Zeitgeber Times and subdivided according to evaluation times of behavioral (open field test and elevated plus-maze test) and biochemistry (corticosterone, melatonin, and glucose levels in serum) parameters. There were temporal patterns within a course of 24h in anxiety-like behaviors and glucose levels. Circadian rhythm to corticosterone and melatonin levels was confirmed and a single session of stress can disrupt these temporal patterns. We showed an immediate disruptive effect of stress in biomarkers levels and a delayed appearance of behavioral and locomotion pattern disruption.

• 出版日期2018