New Rapid Screening Method for Anti-Aging Compounds Using Budding Yeast and Identification of Beauveriolide I as a Potent Active Compound

作者：Nakaya Shigeru; Mizuno Saki; Ishigami Hiroki; Yamakawa Yasuhiro; Kawagishi Hirokazu; Ushimaru Takashi^*

来源：Bioscience Biotechnology and Biochemistry, 2012, 76(6): 1226-1228.

DOI：10.1271/bbb.110872

• anti-aging
• beauveriolide I
• budding yeast
• Cordyceps militaris

The chronological lifespan (CLS) of budding yeast is a model for the aging of post-mitotic cells in higher eukaryotes. We report here the development of a new method to assess yeast CLS. The new assay is simple, convenient and labor-saving. We applied this new method to screen natural compounds isolated from mushrooms and discovered beauveriolide I as a potent anti-aging agent.

• 出版日期2012-6