F-box proteins: Keeping the epithelial-to-mesenchymal transition (EMT) in check

作者：Diaz Victor M; de Herreros Antonio Garcia

来源：Seminars in Cancer Biology, 2016, 36: 71-79.

DOI：10.1016/j.semcancer.2015.10.003

• EMT
• Snail
• Twist
• Zeb
• F-box
• Ubiquitination
• Proteasome
• Cancer

F-box proteins are the key recognition subunit of multimeric E3 ubiquitin ligase complexes that participate in the proteasome degradation of specific substrates. In the last years, a discrete number of F-box proteins have been shown to regulate the epithelial-to-mesenchymal transition (EMT), a process defined by a rapid change of cell phenotype, the loss of epithelial characteristics and the acquisition of a more invasive phenotype. Specific EMT transcription factors (EMT-TFs), such as Snail, Slug, Twist and Zeb, control EMT induction both during development and in cancer. These EMT-TFs are short-lived proteins that are targeted to the proteasome system by specific F-box proteins, keeping them at low levels. F-box proteins also indirectly regulate the EMT process by controlling EMT inducers, such as Notch, c-Myc or mTOR. Here we summarize the role that these F-box proteins (Fbxw1, Fbxw7, Fbxl14, Fbxl5, Fbxo11 and Fbxo45) play in controlling EMT during development and cancer progression, a process dependent on post-translational modifications that govern their interaction with target proteins.

• 出版日期2016-2