Antifungal susceptibility of dermatophytes isolated from patients with chronic renal failure

作者：Magagnin Cibele Massotti; Ottonelli Stopiglia Cheila Denise; Vieira Fabiane Jamono; Heidrich Daiane; Machado Madeline; Vetoratto Gerson; Lamb Flavia Maria; Scroferneker Maria Lucia

来源：Anais Brasileiros de Dermatologia, 2011, 86(4): 694-701.

• Antifungal agents
• Arthrodermataceae
• Kidney failure chronic
• Mycoses

BACKGROUND: The prevalence of dermatophytosis in the general population is high, particularly in patients with chronic renal failure. Treatment requires the use of topical and/or systemic anti fun gal drugs. The efficacy of anti fun gal agents for the treatment of dermatophytosis has yet to be evaluated. Studies evaluating the in vitro activity of anti fun gal agents are rare, particularly in filamentous fungi.
OBJECTIVE: To evaluate the susceptibility profile of different species of dermatophytes isolated from patients with chronic renal failure to nine anti fun gal drugs available on the market for the treatment of dermatophytosis.
METHODS: Twenty-six isolates of dermatophytes obtained from patients with chronic renal failure were analyzed with respect to their susceptibility to nine anti fun gal agents (ketoconazole, ciclopirox olamine, fluconazole, griseofulvin, itraconazole, miconazole, piroctone olamine, terbinafine and tioconazole), using the broth microdilution method proposed by the Clinical and Laboratory Standards Institute (CLSI) and adapted for dermatophytes.
RESULTS: Of the anti fun gal agents tested, the best results in terms of sensitivity were found with terbinafine and tioconazole, while the anti fun gal activity of fluconazole was found to be weak, particularly against strains of M. gypseum. Ciclopirox olamine, although less effective than terbinafine, also yielded satisfactory results.
CONCLUSIONS: In general, the sensitivity profile of the anti fun gal agents tested in this study was similar to results obtained in previous studies, con fir ming the need to determine which species is causing the dermatophytosis given that anti fun gal susceptibility varies from one species to another. Furthermore, the present findings show the importance of conducting in vitro sensitivity tests, since the sensitivity profile may differ among isolates of the same species.

• 出版日期2011-8